High-pressure Homogenizer Applications
Application Introduction
Biological articles
Cell disruption
Applicable type of bacteria
E. coli, Yeast, Algal cells, Animal cells, Insect cells
Crushing principle
Plunger movement carries sample to a valve assembly which size can be adjusted. Samples received ultrahigh pressures squeeze, through the specific slit width. Instantaneous release of pressure to high-speed crash in the homogenizing valve. Bring about cavitation, impace effect shearing effect:So as to achieve a homogenous, emulsification, dispersion effect
Techniques
• > 99% fragmentation rate
• Built-in temperature control device:direct cooling of the working part,the temperature can be controlled at below 10 °C, the samples had no time in with high temperature residen
• PLC control: optional PLC control systems, production data monitoring, collection and output
• Modular design: The device fully modular design, can achieve SIP / CIP
• Resuspended bacterial system can be configured
• Compliance with GMP / FDA requirements
Pharmaceutical, fine chemical
Applicable type of bacteria
Pharmaceutical : Emulsifier, Suspension and other types of drugs
Fine chemical : Nanospheres, Conductive material
Techniques
Uniformity control | Particle size control | Temperature control | Data record |
---|---|---|---|
( Two-level homogeneous ) • The samples could be homogenized and dispersed in first stag • The sample would be further dispersed evenly in the second stage • Agglomerated particles would be dispersed and PDI is less than 0.1 |
• Fat emulsion particle size <0.2um • Liposome particle size<0. 1um • Fine Chemical System Stability |
Internal and external temperature control at the same time, can be adjusted within the range of 5-100 °C | Monitor the whole process, in line with GMP / FDA standards |
Pharmacy System